Department of Orthopedic Surgery, Stanford University, Stanford, CA 94305, USA.
J Biomed Mater Res B Appl Biomater. 2013 Aug;101(6):972-80. doi: 10.1002/jbm.b.32905. Epub 2013 Mar 26.
Porous calcium polyphosphate (CPP) structures with 30 volume percent porosity and made by solid freeform fabrication (SFF) were implanted in rabbit femoral condyle sites for 6-wk periods. Two forms of SFF implants with different stacked layer orientation were made in view of prior studies reporting on anisotropic/orthotropic mechanical properties of structures so formed. In addition, porous CPP implants of equal volume percent porosity made by conventional sintering and machining methods were prepared. Bone ingrowth and in vivo degradation of the three different implant types were compared using back-scattered scanning electron microscopy (BS-SEM) of implant samples and quantitative analysis of the images. The results indicated bone ingrowth with all samples resulting in 30-40% fill of available porosity by bone within the 6-wk period. In the 6-wk in vivo period, approximately 7-9% loss of CPP by degradation had occurred.
采用固体自由成形制造（SFF）技术制备了孔隙率为 30%的多孔磷酸钙（CPP）结构，将其植入兔股骨髁部位，植入时间为 6 周。鉴于先前的研究报告了所形成结构的各向异性/正交各向异性机械性能，因此采用了两种不同堆叠层取向的 SFF 植入物形式。此外，还通过传统的烧结和机械加工方法制备了具有相同孔隙率体积分数的多孔 CPP 植入物。通过对植入物样本进行背散射扫描电子显微镜（BS-SEM）和图像定量分析，比较了三种不同植入物类型的骨内生长和体内降解情况。结果表明，所有样本在 6 周内通过骨生长填充了 30-40%的可用孔隙率。在 6 周的体内期间，CPP 降解约 7-9%。
