Botiss Biomaterials GmbH, Hauptstr. 28, 15806 Zossen, Germany.
Department of Anatomy, Histology and Embryology, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek 31000, Croatia.
Int J Mol Sci. 2018 Oct 24;19(11):3308. doi: 10.3390/ijms19113308.
Three-dimensional (3D) printing has become an important tool in the field of tissue engineering and its further development will lead to completely new clinical possibilities. The ability to create tissue scaffolds with controllable characteristics, such as internal architecture, porosity, and interconnectivity make it highly desirable in comparison to conventional techniques, which lack a defined structure and repeatability between scaffolds. Furthermore, 3D printing allows for the production of scaffolds with patient-specific dimensions using computer-aided design. The availability of commercially available 3D printed permanent implants is on the rise; however, there are yet to be any commercially available biodegradable/bioresorbable devices. This review will compare the main 3D printing techniques of: stereolithography; selective laser sintering; powder bed inkjet printing and extrusion printing; for the fabrication of biodegradable/bioresorbable bone tissue scaffolds; and, discuss their potential for dental applications, specifically augmentation of the alveolar ridge.
三维(3D)打印已成为组织工程领域的重要工具,其进一步发展将带来全新的临床可能性。与缺乏明确结构和支架间可重复性的传统技术相比,3D 打印具有可控制特性(如内部结构、孔隙率和连通性)的组织支架的能力具有很大的吸引力。此外,3D 打印允许使用计算机辅助设计生产具有患者特定尺寸的支架。可商用的 3D 打印永久性植入物的可用性正在增加;然而,目前还没有任何可商用的可生物降解/可吸收的设备。本综述将比较用于制造可生物降解/可吸收骨组织支架的主要 3D 打印技术:立体光刻、选择性激光烧结、粉末床喷墨打印和挤出打印;并讨论它们在牙科应用中的潜力,特别是牙槽嵴的增强。