Joyeux M, Rolland A, Fleurentin J, Mortier F, Dorfman P
Centre des Sciences de l'Environnement, Université de Metz, France.
Planta Med. 1990 Apr;56(2):171-4. doi: 10.1055/s-2006-960918.
Tert-butyl hydroperoxide induces in freshly isolated rat hepatocytes malonaldehyde formation and lacticodehydrogenase and aspartate amino-transferase leakage. This model, when adapted to crude extracts, permits the demonstration of both anti-lipoperoxidant and antihepatotoxic activity of reference products like quercetin and silymarin and plant extracts like Rosmarinus officinalis and Eschscholzia californica.
叔丁基过氧化氢可诱导新鲜分离的大鼠肝细胞中丙二醛的形成以及乳酸脱氢酶和天冬氨酸转氨酶的泄漏。当该模型应用于粗提物时，可用于证明槲皮素、水飞蓟宾等参考产品以及迷迭香和加利福尼亚罂粟等植物提取物的抗脂质过氧化和抗肝毒性活性。
