一些大鼠肝脏氧化应激的体外/体内化学诱导实验模型。
Some in vitro/in vivo chemically-induced experimental models of liver oxidative stress in rats.
作者信息
Simeonova Rumyana, Kondeva-Burdina Magdalena, Vitcheva Vessela, Mitcheva Mitka
机构信息
Laboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University 2 Dunav Street, 1000 Sofia, Bulgaria.
出版信息
Biomed Res Int. 2014;2014:706302. doi: 10.1155/2014/706302. Epub 2014 Jan 16.
Abstract
Oxidative stress is critically involved in a variety of diseases. Reactive oxygen species (ROS) are highly toxic molecules that are generated during the body's metabolic reactions and can react with and damage some cellular molecules such as lipids, proteins, or DNA. Liver is an important target of the oxidative stress because of its exposure to various prooxidant toxic compounds as well as of its metabolic function and ability to transform some xenobiotics to reactive toxic metabolites (as ROS). To investigate the processes of liver injuries and especially liver oxidative damages there are many experimental models, some of which we discuss further.
摘要
氧化应激与多种疾病密切相关。活性氧（ROS）是高毒性分子，在机体代谢反应过程中产生，可与脂质、蛋白质或DNA等一些细胞分子发生反应并造成损伤。肝脏是氧化应激的重要靶点，这是因为它会接触各种促氧化毒性化合物，还因其代谢功能以及将某些外源性物质转化为活性毒性代谢产物（如ROS）的能力。为了研究肝损伤尤其是肝脏氧化损伤的过程，有许多实验模型，我们将进一步讨论其中一些模型。
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