Agnihotri Rupali, Gaur Sumit
Department of Periodontics, Manipal University, Manipal, India.
Geriatr Gerontol Int. 2014 Jan;14(1):8-22. doi: 10.1111/ggi.12062. Epub 2013 Mar 26.
Periodontitis and rheumatoid arthritis are chronic inflammatory diseases commonly seen in the elderly. It has been proposed that the two conditions are interrelated and influence the severity of each other. Recently, the role of Porphyromonas gingivalis, a periodontopathogen, has been explained in the pathogenesis and progression of rheumatoid arthritis. It can be inferred from the present review that the two conditions share a common pathobiology, genetics and environmental risk factors. Furthermore, a thorough understanding of the aforementioned mechanisms might enable the development of conjoint treatment modalities beneficial in treating the geriatric population afflicted by both the disorders.
牙周炎和类风湿性关节炎是老年人常见的慢性炎症性疾病。有人提出这两种疾病相互关联且会影响彼此的严重程度。最近，牙周病原体牙龈卟啉单胞菌在类风湿性关节炎的发病机制和进展中的作用已得到解释。从本综述中可以推断，这两种疾病具有共同的病理生物学、遗传学和环境风险因素。此外，对上述机制的深入理解可能有助于开发联合治疗模式，对同时患有这两种疾病的老年人群有益。
