Infection and Immunity Research Group, University of Glasgow Dental School, School of Medicine, Glasgow, UK.
Mucosal Immunol. 2012 Mar;5(2):112-20. doi: 10.1038/mi.2011.66. Epub 2012 Jan 25.
Epidemiological data indicate a link between rheumatoid arthritis (RA) and periodontal disease (PD). In vitro and in vivo studies have sought to dissect potential mechanisms by which PD may contribute to initiation and progression of RA. However, these are both multifactorial, chronic diseases, and their complex etiologies and pathogenesis themselves remain incompletely understood. Could there really be an etiological link or does this simply represent a statistical coincidence muddied by common risk factors? This review seeks to provide background on these two diseases in the context of recent discoveries suggesting that their pathogenesis may be related. In particular, the process of citrullination, a post-translational protein modification, has been highlighted as a process common to both diseases. The evidence for a relationship between the diseases is explored and its potential mechanisms discussed.
流行病学数据表明类风湿关节炎（RA）和牙周病（PD）之间存在关联。体外和体内研究试图剖析 PD 可能引发和促进 RA 发展的潜在机制。然而，这两种疾病都是多因素的慢性疾病，其复杂的病因和发病机制本身仍不完全清楚。两者之间真的存在病因学联系，还是这种关联只是因为常见的风险因素而造成的统计学上的巧合？本文综述了这两种疾病的背景，以及最近的发现表明它们的发病机制可能相关。特别是，翻译后蛋白质修饰过程中的瓜氨酸化已被强调为两种疾病共有的过程。探讨了这两种疾病之间的关系证据，并讨论了其潜在机制。
