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体内甲状腺声触诊影像：一项初步研究。

In vivo thyroid vibro-acoustography: a pilot study.

机构信息

Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

出版信息

BMC Med Imaging. 2013 Mar 27;13:12. doi: 10.1186/1471-2342-13-12.

DOI:10.1186/1471-2342-13-12
PMID:23530993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3618245/
Abstract

BACKGROUND

The purpose of this study was to evaluate the utility of a noninvasive ultrasound-based method, vibro-acoustography (VA), for thyroid imaging and determine the feasibility and challenges of VA in detecting nodules in thyroid.

METHODS

Our study included two parts. First, in an in vitro study, experiments were conducted on a number of excised thyroid specimens randomly taken from autopsy. Three types of images were acquired from most of the specimens: X-ray, B-mode ultrasound, and vibro-acoustography. The second and main part of the study includes results from performing VA and B-mode ultrasound imaging on 24 human subjects with thyroid nodules. The results were evaluated and compared qualitatively.

RESULTS

In vitro vibro-acoustography images displayed soft tissue structures, microcalcifications, cysts and nodules with high contrast and no speckle. In this group, all of US proven nodules and all of X-ray proven calcifications of thyroid tissues were detected by VA. In vivo results showed 100% of US proven calcifications and 91% of the US detected nodules were identified by VA, however, some artifacts were present in some cases.

CONCLUSIONS

In vitro and in vivo VA images show promising results for delineating the detailed structure of the thyroid, finding nodules and in particular calcifications with greater clarity compare to US. Our findings suggest that, with further development, VA may be a suitable imaging modality for clinical thyroid imaging.

摘要

背景

本研究旨在评估一种非侵入性的超声基方法（声触诊组织量化技术）在甲状腺成像中的应用，并确定其在甲状腺结节检测中的可行性和挑战。

方法

我们的研究包括两部分。首先，在一项体外研究中，对从尸检中随机取出的一些甲状腺标本进行了实验。从大多数标本中获得了三种类型的图像：X 射线、B 型超声和声触诊组织量化技术。研究的第二部分和主要部分包括对 24 例甲状腺结节患者进行声触诊组织量化技术和 B 型超声成像的结果。对结果进行了定性评估和比较。

结果

体外声触诊组织量化技术图像显示软组织结构、微钙化、囊肿和结节具有高对比度且无斑点。在这组中，VA 检测到了所有 US 证实的结节和所有 X 射线证实的甲状腺组织钙化。体内结果显示，VA 可识别 100%的 US 证实的钙化和 91%的 US 检测到的结节，但在某些情况下存在一些伪影。

结论

体外和体内声触诊组织量化技术图像在描绘甲状腺的详细结构、发现结节特别是钙化方面显示出有前景的结果，与 US 相比，具有更高的清晰度。我们的发现表明，随着进一步的发展，声触诊组织量化技术可能成为一种适合临床甲状腺成像的成像方式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99f9/3618245/b6b66694adcf/1471-2342-13-12-12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99f9/3618245/b489f15f3f06/1471-2342-13-12-1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99f9/3618245/ba670b9a6a4b/1471-2342-13-12-11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99f9/3618245/b6b66694adcf/1471-2342-13-12-12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99f9/3618245/b489f15f3f06/1471-2342-13-12-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99f9/3618245/c7bd55233152/1471-2342-13-12-2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99f9/3618245/6e7bf914d429/1471-2342-13-12-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99f9/3618245/607b1b6b6841/1471-2342-13-12-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99f9/3618245/1b5b397da32a/1471-2342-13-12-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99f9/3618245/6c7ea2341462/1471-2342-13-12-8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99f9/3618245/584ef382abc0/1471-2342-13-12-9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99f9/3618245/d9e43c56c802/1471-2342-13-12-10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99f9/3618245/ba670b9a6a4b/1471-2342-13-12-11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99f9/3618245/b6b66694adcf/1471-2342-13-12-12.jpg

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