Beitler J J, McCormick B, Ellsworth R M, Abramson D H, Anderson L L, Loffredo C
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY.
Radiology. 1990 Jul;176(1):275-8. doi: 10.1148/radiology.176.1.2353101.
From 1968 to 1987, 123 consecutive patients with nonmetastatic choroidal melanoma were treated with cobalt-60 plaques. One hundred sixteen patients were followed up for a mean of 3.8 years. Twenty patients had local failure, and 14 patients had distant failure. Complications included 32 cataracts, and seven enucleations were required. Local recurrence did not correlate with tumor height, tumor volume, dose, or dose rate. Increased volume (P = .004) and height (P = .01) correlated with increased rates of distant metastases. Dose adjusted for volume did not correlate with the rate of metastases.
1968年至1987年，123例连续性非转移性脉络膜黑色素瘤患者接受了钴-60敷贴器治疗。116例患者接受了平均3.8年的随访。20例患者出现局部失败，14例患者出现远处失败。并发症包括32例白内障，需要进行7例眼球摘除术。局部复发与肿瘤高度、肿瘤体积、剂量或剂量率无关。体积增加（P = .004）和高度增加（P = .01）与远处转移率增加相关。根据体积调整的剂量与转移率无关。
