Rudin A, Bosaeus I, Hessov I
Department of Medicine II, Gothenburg University, Sahlgrenska Hospital, Göteborg, Sweden.
Scand J Clin Lab Invest. 1990 May;50(3):273-7. doi: 10.3109/00365519009091578.
In 20 patients with Bartter's syndrome, who had a serum potassium concentration of 2.75 +/- 0.29 mmol/l (mean +/- SD), the total body potassium (TBK) was measured and compared with a predicted value obtained from regression equations based on age, sex, body height and weight. A significant difference was found between the observed and predicted TBK (mean -320 +/- 306 mmol, p less than 0.01). A positive correlation existed between the serum potassium concentration and the ratio observed TBK/predicted TBK. However, the average fractional reduction in TBK (-11%) was less than the average fractional decrease in serum potassium concentration (-32%). Muscle biopsy specimens were obtained from four patients with Bartter's syndrome and 10 control subjects for analyses of potassium and magnesium. The serum concentrations of potassium and magnesium were decreased in these patients. The potassium content in muscle tissue was lower in two of four patients, but no difference in the amount of magnesium was observed.
在20例巴特综合征患者中，其血清钾浓度为2.75±0.29 mmol/l（均值±标准差），测量了总体钾（TBK），并与根据年龄、性别、身高和体重通过回归方程获得的预测值进行比较。观察到的TBK与预测的TBK之间存在显著差异（均值-320±306 mmol，p<0.01）。血清钾浓度与观察到的TBK/预测的TBK比值之间存在正相关。然而，TBK的平均分数降低（-11%）小于血清钾浓度的平均分数降低（-32%）。从4例巴特综合征患者和10例对照受试者获取肌肉活检标本，用于分析钾和镁。这些患者的血清钾和镁浓度降低。4例患者中有2例肌肉组织中的钾含量较低，但未观察到镁含量的差异。
