Ishikawa Y, Wada T
Jpn Circ J. 1979 Aug;43(8):757-67. doi: 10.1253/jcj.43.757.
Escape from sodium and potassium retaining actions of aspirin-like drugs used in a patient with Bartter's syndrome. An analysis was done with regard to the mode of escapes from sodium and potassium retaining actions of aspirin-like drugs in a patient with Bartter's syndrome. In the indomethacin therapy of the syndrome, there was a delay in the initiation of potassium escape as compared to sodium escape, whereas no delay was seen in the ibuprofen therapy. This delay was probably related to the direct or indirect inhibition of sodium-potassium exchange in the distal nephrons. The course of aspirin therapy went midway between the above two. In the spironolactone therapy, the mode of escape was a mirror image of the one in the indomethacin therapy. Also, in a patient with rheumatoid arthritis, but without Bartter's syndrome, the escapes from the effects of indomethacin were seen. In order to understand the effect of these drugs on potassium excretion in Bartter's syndrome, some other intrarenal events, such as the influence on chloride transport in the loop of Henle leading to potassium conservation, may have to be considered.
巴德综合征患者对阿司匹林类药物钠潴留和钾潴留作用的逃避。对巴德综合征患者逃避阿司匹林类药物钠潴留和钾潴留作用的方式进行了分析。在该综合征的吲哚美辛治疗中，与钠逃避相比，钾逃避的起始出现延迟，而在布洛芬治疗中未观察到延迟。这种延迟可能与远端肾单位中钠钾交换的直接或间接抑制有关。阿司匹林治疗的过程介于上述两者之间。在螺内酯治疗中，逃避模式与吲哚美辛治疗中的模式相反。此外，在一名类风湿性关节炎患者（但无巴德综合征）中，也观察到了对吲哚美辛作用的逃避。为了了解这些药物对巴德综合征患者钾排泄的影响，可能必须考虑一些其他肾内事件，例如对亨利袢中氯转运的影响导致钾的保留。
