Soft Matter Chemistry, Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
Chem Commun (Camb). 2013 May 7;49(35):3649-51. doi: 10.1039/c3cc38926j. Epub 2013 Mar 27.
Sets of complementary lipidated coiled-coil forming peptides that fuse membrane fusion have been designed. The influence of the coiled-coil motif on the rate of liposome fusion was studied, by varying the number of heptad repeats. We found that an increased coiled-coil stability of complementary peptides translates into increased rates of membrane fusion of liposomes.
已经设计了一系列互补的脂化卷曲螺旋形成肽，它们能够融合膜融合。通过改变七肽重复数来研究卷曲螺旋基序对脂质体融合速率的影响。我们发现互补肽的卷曲螺旋稳定性增加会转化为脂质体膜融合速率的增加。
