Sawai T, Murakami K, Ohtani Y, Kurkinnen M, Kyogoku M, Hayashi M
Department of Pathology, University of Medicine and Dentistry, New Jersey-Robert Wood Johnson Medical School, Piscataway.
Tohoku J Exp Med. 1990 Mar;160(3):285-6. doi: 10.1620/tjem.160.285.
We identified the cells synthesizing stromelysin to be synovial cells in the synovial tissue from four biopsy cases with rheumatoid arthritis (RA) by in situ hybridization and immunohistochemical studies. In the cases which showed severe inflammation of synovia such as well developed lymphoid follicle and diffuse inflammatory infiltration, synovial cells located only in the superficial layer of synovial tissues showed abundant mRNA and enzymic protein of stromelysin.
通过原位杂交和免疫组织化学研究，我们确定在4例类风湿性关节炎（RA）活检病例的滑膜组织中，合成基质溶解素的细胞为滑膜细胞。在滑膜显示严重炎症（如发育良好的淋巴滤泡和弥漫性炎症浸润）的病例中，仅位于滑膜组织表层的滑膜细胞显示出丰富的基质溶解素mRNA和酶蛋白。
