Sahin Deniz Gören, Durak Beyhan, Gündüz Eren, Artan Sevilhan, Akay Olga Meltem
Department of Hematology, School of Medicine, Eskisehir Osmangazi University, 26480 Eskisehir, Turkey.
Case Rep Genet. 2013;2013:462896. doi: 10.1155/2013/462896. Epub 2013 Feb 27.
Acute myelogenous leukemia (AML) develops as the consequence of a series of genetic changes in a hematopoietic precursor cell. Specific cytogenetic abnormalities have been identified by karyotype analysis in AML. One of the rare chromosomal abnormalities is a dicentric chromosome, which is defined as an aberrant chromosome having two centromeres. In the literature, a limited number of cases have been reported with dic(1;15) in myeloid disorders, but only one case has been reported with in acute megakaryoblastic leukemia. Herein, we report a case of acute myelogenous leukemia without maturation with a dic(1;15)(p11;p11), resulting in trisomy of the long arm of chromosome 1. To date, this is the second case of dic(1;15) in acute myelogenous leukemia and the first case in acute myeloblastic leukemia without maturation.
急性髓系白血病（AML）是造血前体细胞发生一系列基因变化的结果。通过AML的核型分析已鉴定出特定的细胞遗传学异常。罕见的染色体异常之一是双着丝粒染色体，其定义为具有两个着丝粒的异常染色体。在文献中，仅有少数髓系疾病伴dic(1;15)的病例报道，而急性巨核细胞白血病中仅有1例报道。在此，我们报告1例急性未成熟型髓系白血病伴dic(1;15)(p11;p11)，导致1号染色体长臂三体。迄今为止，这是急性髓系白血病中第二例dic(1;15)，也是急性未成熟型髓系白血病中的首例。
