Leonardi Fabio, Costa Giovanna Lucrezia, Stagnoli Alice, Zubin Elena, Boschi Paolo, Sabbioni Alberto, Simonazzi Barbara
Department of Veterinary Science, University of Parma, via del Taglio 10, 43126 Parma, Italy (Leonardi, Stagnoli, Zubin, Boschi, Sabbioni, Simonazzi); Department of Veterinary Sciences, Polo Universitario dell'Annunziata, 98168, University of Messina, Italy (Costa).
Can Vet J. 2019 Jan;60(1):55-59.
This study assessed the effects of a combination of dexmedetomidine and butorphanol on the Schirmer tear test I (STT I) values in dogs. Ninety-eight dogs were sedated with an intramuscular injection of a combination of dexmedetomidine, 5 μg/kg body weight (BW), and butorphanol, 0.2 mg/kg BW. The effects of dexmedetomidine were reversed by administering atipamezole at the end of the procedure. The combination of dexmedetomidine and butorphanol significantly decreased tear production 15 minutes after sedation. The STT I values 15 minutes after reversal of dexmedetomidine with atipamezole were significantly higher than the STT I values 15 minutes after sedation but were significantly lower than the STT I values before sedation. Gender, weight, duration of sedation, right or left eye did not affect STT I values after sedation. It is recommended that dogs sedated with a combination of dexmedetomidine and butorphanol be treated with a tear substitute to combat decreased tear production.
本研究评估了右美托咪定和布托啡诺联合用药对犬施密特氏泪液试验I(STT I)值的影响。98只犬通过肌肉注射5μg/kg体重的右美托咪定和0.2mg/kg体重的布托啡诺进行镇静。在操作结束时给予阿替美唑以逆转右美托咪定的作用。右美托咪定和布托啡诺联合用药在镇静后15分钟显著减少泪液分泌。用阿替美唑逆转右美托咪定作用后15分钟的STT I值显著高于镇静后15分钟的STT I值,但显著低于镇静前的STT I值。性别、体重、镇静持续时间、右眼或左眼不影响镇静后的STT I值。建议用右美托咪定和布托啡诺联合用药镇静的犬使用人工泪液替代物治疗以应对泪液分泌减少。