School of Veterinary Medicine, Department of Veterinary Medical Science, Louisiana State University, Baton Rouge, Louisiana, United States of America.
College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, United States of America.
PLoS One. 2023 Jul 3;18(7):e0288088. doi: 10.1371/journal.pone.0288088. eCollection 2023.
In people, the dose of propofol (DOP) required for procedural sedation and anesthesia decreases significantly with age. The objective of this study was to determine if the DOP required to perform endotracheal intubation decreases with age in dogs.
Retrospective case series.
1397 dogs.
Data from dogs anesthetized at referral center (2017-2020) were analyzed with three multivariate linear regression models with backward elimination using a combination of either absolute age, physiologic age, or life expectancy (ratio between age at the time of anesthetic event and expected age of death for each breed obtained from previous literature) as well as other factors as independent variables, and DOP as the dependent variable. The DOP for each quartile of life expectancy (<25%, 25-50%, 50-75%, 75-100%, >100%) was compared using one-way ANOVA. Significance was set at alpha = 0.025.
Mean age was 7.2 ± 4.1 years, life expectancy 59.8 ± 33%, weight 19 ± 14 kg, and DOP 3.76 ± 1.8 mg kg-1. Among age models, only life expectancy was a predictor of DOP (-0.37 mg kg-1; P = 0.013) but of minimal clinical importance. The DOP by life age expectancy quartile was 3.9 ± 2.3, 3.8 ± 1.8, 3.6 ± 1.8, 3.7 ± 1.7, and 3.4 ± 1.6 mg kg-1, respectively (P = 0.20). Yorkshire Terrier, Chihuahua, Maltese, mixed breed dogs under 10 kg, and Shih Tzu required higher DOP. Status of neutered male, ASA E, and Boxer, Labrador and Golden Retriever breeds decreased DOP, along with certain premedication drugs.
In contrast to what is observed in people, an age cut-off predictive of DOP does not exist. Percentage of elapsed life expectancy along with other factors such as breed, premedication drug, emergency procedure, and reproductive status significantly alter DOP. In older dogs, the dose of propofol can be adjusted based on their elapsed life expectancy.
在人类中，进行程序镇静和麻醉所需的丙泊酚剂量（DOP）随年龄显著下降。本研究的目的是确定在狗中进行气管内插管所需的 DOP 是否随年龄而降低。
回顾性病例系列。
1397 只狗。
使用具有向后消除的三个多元线性回归模型，分析了在转诊中心麻醉的狗的数据，这些模型使用绝对年龄、生理年龄或预期寿命（从先前文献中获得的每种品种在麻醉事件时的年龄与预期死亡年龄的比值）以及其他因素作为自变量，并将 DOP 作为因变量。使用单向方差分析比较了每个预期寿命四分位数（<25%、25-50%、50-75%、75-100%、>100%）的 DOP。将显著性设置为 alpha = 0.025。
平均年龄为 7.2 ± 4.1 岁，预期寿命 59.8 ± 33%，体重 19 ± 14 kg，DOP 为 3.76 ± 1.8 mg kg-1。在年龄模型中，只有预期寿命是 DOP 的预测因素（-0.37 mg kg-1；P = 0.013），但临床意义不大。按预期寿命四分位数的 DOP 分别为 3.9 ± 2.3、3.8 ± 1.8、3.6 ± 1.8、3.7 ± 1.7 和 3.4 ± 1.6 mg kg-1（P = 0.20）。约克夏梗、吉娃娃、马尔济斯犬、10 公斤以下的混合犬和西施犬需要更高的 DOP。去势雄性、ASA E 以及拳师犬、拉布拉多犬和金毛猎犬等品种降低了 DOP，同时还有某些术前药物。
与在人类中观察到的情况相反，不存在预测 DOP 的年龄截止值。预期寿命的百分比以及品种、术前药物、紧急程序和生殖状态等其他因素会显著改变 DOP。在老年犬中，可以根据其预期寿命来调整丙泊酚的剂量。
