14C-甲氧苄啶在雄性Mol:WIST和Mol:PVG大鼠中黑色素亲和力的研究。
A study on melanin affinity of 14C-trimethoprim in male Mol:WIST and Mol:PVG rats.
作者信息
Ingebrigtsen K, Skoglund L A, Nafstad I
机构信息
Department of Pharmacology and Toxicology, Norwegian College of Veterinary Medicine, Oslo.
出版信息
Z Versuchstierkd. 1990;33(2):73-7.
Hooded (Mol:PVG) and albino (Mol:WIST) rats were used to study the distribution pattern of 14C-trimethoprim by whole body autoradiography. Accumulation of radioactivity was demonstrated in the uveal tract of the eye and the pigmented parts of the skin in the hooded rats. No radioactivity was present in the corresponding tissues in the albino rats. This difference in the distribution pattern was interpreted to reflect binding to melanin of 14C-trimethoprim and/or its metabolites.
采用有帽大鼠（品系：PVG）和白化大鼠（品系：WIST），通过全身放射自显影研究14C-甲氧苄啶的分布模式。在有帽大鼠的眼葡萄膜和皮肤色素沉着部位显示有放射性积聚。白化大鼠的相应组织中未出现放射性。这种分布模式的差异被解释为反映了14C-甲氧苄啶及其代谢产物与黑色素的结合。
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