Muller J E
Harvard Medical School, Boston, Massachusetts 02115.
Am J Cardiol. 1990 Jun 19;65(23):51K-53K. doi: 10.1016/0002-9149(90)91281-a.
Although many new drugs useful in the treatment of congestive heart failure have been introduced during the past 25 years, spironolactone continues to have an important role in the management of this condition. Spironolactone adds to the activity of the thiazide and loop diuretics to enhance the elimination of sodium and water. Furthermore, unwanted electrolyte disturbances such as hypokalemia and hypomagnesemia, associated with the administration of other classes of diuretics, can be minimized with spironolactone.
尽管在过去25年里已经引入了许多用于治疗充血性心力衰竭的新药，但螺内酯在这种疾病的管理中仍然发挥着重要作用。螺内酯可增强噻嗪类和袢利尿剂的活性，以促进钠和水的排泄。此外，与使用其他类利尿剂相关的低钾血症和低镁血症等不良电解质紊乱，可通过使用螺内酯将其降至最低。
