Monsén U, Sorstad J, Hellers G, Johansson C
Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
Am J Gastroenterol. 1990 Jun;85(6):711-6.
In a population-based study of 1274 patients with ulcerative colitis (UC), the overall prevalence of extracolonic diagnoses was 21%. Seventy percent of patients with extracolonic diagnoses had extensive colitis. Patients without extracolonic diagnoses had only 28% extensive colitis (p less than 0.001), compared with 37% in the entire test population. The prevalence was higher in familial UC (p less than 0.05). The extracolonic diagnoses could be classified into two major groups, activity related and autoimmune, with regard to the extent and activity of UC and to the effects of medical and surgical treatment. Three hundred sixty-four diagnoses were distributed in 271 UC patients. It is concluded that extracolonic diagnoses are less frequent in an unselected patient group. However, extracolonic diagnoses are associated with the extent of UC at the time of diagnosis and with familial UC, and they can be classified as either activity related or autoimmune, with characteristic combinations of several extracolonic diagnoses occurring in 25% of the 271 patients.
在一项针对1274例溃疡性结肠炎（UC）患者的基于人群的研究中，结肠外诊断的总体患病率为21%。有结肠外诊断的患者中，70%患有广泛性结肠炎。没有结肠外诊断的患者仅有28%患有广泛性结肠炎（p<0.001），而整个测试人群中这一比例为37%。家族性UC的患病率更高（p<0.05）。就UC的范围和活动以及药物和手术治疗的效果而言，结肠外诊断可分为两个主要类别，即与活动相关的和自身免疫性的。364例诊断分布在271例UC患者中。研究得出结论，在未经过挑选的患者群体中，结肠外诊断的发生率较低。然而，结肠外诊断与诊断时UC的范围以及家族性UC相关，并且它们可分为与活动相关的或自身免疫性的，在271例患者中有25%出现了几种结肠外诊断的特征性组合。
