Toader Elena
Universitatea de Medicină si Farmacie "Gr.T. Popa" Iaşi, Facultatea de Bioinginerie, Institutul de Gastroenterologie si Hepatologie, Iaşi.
Rev Med Chir Soc Med Nat Iasi. 2007 Oct-Dec;111(4):845-51.
Ulcerative colitis (UC) is a chronic disease clinically manifest either by bowel symptoms alone or extraintestinal symptoms.
Our prospective study included 635 patients with ulcerative colitis (334 males and 301 females, mean age 37.54 +/- 13.84, range 20-70 years). The presence of the common extraintestinal symptoms (ES) was analyzed.
Of the 635 investigated patients, these symptoms were found in 83 (13%, 49 males and 34 females, mean age 41.6 +/- 13.95 range 21-70). Patients with ES suffered longer from UC on the average, that is 60.6 years. Most commonly ES involved the joints, 38 (45.8%) patients, hepatobiliary, 28 patients (33.7%), skin, 10 patients (12%) and eyes, 7 patients (8.4%). In 18% of the patients two or more ES were present. ES were clinically detectable after the intestinal symptoms in 81% patients. An increased tendency of ES to occur in patients with a more extensive disease was noticed.
The prevalence of ES in the UC patients from NE Romania is in agreement with data from other countries. The number of ES supports the need for complex follow-up in these patients.
溃疡性结肠炎（UC）是一种慢性病，临床表现为仅出现肠道症状或伴有肠外症状。
我们的前瞻性研究纳入了635例溃疡性结肠炎患者（男性334例，女性301例，平均年龄37.54±13.84岁，范围20 - 70岁）。分析了常见肠外症状（ES）的存在情况。
在635例被调查患者中，发现83例有这些症状（13%，男性49例，女性34例，平均年龄41.6±13.95岁，范围21 - 70岁）。有肠外症状的患者患溃疡性结肠炎的平均时间更长，即60.6年。最常见的肠外症状累及关节，38例（45.8%）患者，肝胆系统，28例患者（33.7%），皮肤，10例患者（12%），眼睛，7例患者（8.4%）。18%的患者存在两种或更多种肠外症状。81%的患者在肠道症状出现后临床上可检测到肠外症状。注意到肠外症状在病情更广泛的患者中出现的倾向增加。
罗马尼亚东北部溃疡性结肠炎患者肠外症状的患病率与其他国家的数据一致。肠外症状的数量支持了对这些患者进行综合随访的必要性。
