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慢性病个体化管理新模式:聚焦炎症性肠病并展望未来。

New pattern of individualized management of chronic diseases: focusing on inflammatory bowel diseases and looking to the future.

作者信息

Guo Xi, Cai Liyang, Cao Yuchen, Liu Zining, Zhang Jiexin, Liu Danni, Jiang Zhujun, Chen Yanxia, Fu Min, Xia Zhaoxia, Yi Guoguo

机构信息

Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

School of Rehabilitation Sciences, Southern Medical University, Guangzhou, Guangdong, China.

出版信息

Front Med (Lausanne). 2023 May 10;10:1186143. doi: 10.3389/fmed.2023.1186143. eCollection 2023.

Abstract

Non-infectious chronic diseases, especially inflammatory bowel diseases (IBDs), hypertension, and diabetes mellitus, are characterized by a prolonged and multisystemic course, and their incidence increases annually, usually causing serious economic burden and psychological stress for patients. Therefore, these diseases deserve scientific and consistent disease management. In addition, the lack of a comprehensive "early disease clues tracking-personalized treatment system-follow-up" model in hospitals also exacerbates this dilemma. Based on these facts, we propose an individualized prediction management system for IBDs based on chronic diseases, focusing on the established IBDs-related prediction models and summarizing their advantages and disadvantages. We call on researchers to pay attention to the integration of models with clinical practice and the continuous correction of models to achieve truly individualized medical treatment for chronic diseases, thus providing substantial value for the rapid diagnosis and adequate treatment of chronic diseases such as IBDs, which follow the "relapse-remission" disease model, and realizing long-term drug use and precise disease management for patients. The goal is to achieve a new level of chronic disease management by scientifically improving long-term medication, precise disease management, and individualized medical treatment, effectively prolonging the remission period and reducing morbidity and disability rates.

摘要

非传染性慢性病,尤其是炎症性肠病(IBD)、高血压和糖尿病,具有病程长和多系统受累的特点,且其发病率逐年上升,通常给患者带来沉重的经济负担和心理压力。因此,这些疾病需要科学且连贯的疾病管理。此外,医院缺乏全面的“疾病早期线索追踪-个性化治疗体系-随访”模式也加剧了这一困境。基于这些事实,我们提出一种基于慢性病的IBD个体化预测管理系统,重点关注已建立的IBD相关预测模型,并总结其优缺点。我们呼吁研究人员关注模型与临床实践的整合以及模型的持续校正,以实现慢性病真正的个体化医疗,从而为遵循“复发-缓解”疾病模式的IBD等慢性病的快速诊断和充分治疗提供重要价值,并实现患者的长期用药和精准疾病管理。目标是通过科学改进长期用药、精准疾病管理和个体化医疗,达到慢性病管理的新水平,有效延长缓解期并降低发病率和残疾率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e968/10231387/588104e5c23a/fmed-10-1186143-g001.jpg

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