俄罗斯欧洲北部居民载脂蛋白-E 的血浆水平。
Plasma levels of apolipoprotein-E in residents of the European North of Russia.
机构信息
Institute of Physiology, Komi Science Center, Ural Branch of Russian Academy of Sciences, Syktyvkar, Russia.
出版信息
Lipids Health Dis. 2013 Mar 27;12:43. doi: 10.1186/1476-511X-12-43.
BACKGROUND
Apolipoprotein-E (apoE) is one of the metabolically active apoproteins and plays an important role in lipid metabolism. However, there are no data on levels of apoE in residents of the North in spite of the fact that specific features of lipid metabolism in the northerners are described. The present work was designed to study plasma levels of apoE in residents of the European North of Russia.
METHODS
A total of 937 native residents of the European North of Russia (463 men and 474 women) aged 13-60 years were included in the study. ApoE concentrations in the blood plasma were measured by immunoturbidimetric method.
RESULTS
Plasma levels of apoE in residents of the European North of Russia were low. ApoE concentrations below the defined normal values were detected in 57.0% of the men and in 59.2% of the women. The mean plasma levels of apoE did not significantly differ in men and women (2.80 mg/dl vs 2.87 mg/dl). Plasma apoE concentrations in residents of the European North of Russia changed with age. Plasma levels of apoE decreased from 13 to 21 years in men and from 13 to 35 years in women and then increased in both sexes (p < 0.001).
CONCLUSION
The limits of variation of plasma apoE levels in residents of the European North of Russia shift towards lower values. Plasma levels of apoE below normal values were observed in approximately half of investigation subjects.
背景
载脂蛋白 E（apoE）是一种代谢活跃的载脂蛋白，在脂质代谢中发挥重要作用。然而，尽管已经描述了北方人的脂质代谢的特定特征，但目前尚无关于北方居民 apoE 水平的数据。本研究旨在研究俄罗斯欧洲北部居民的血浆 apoE 水平。
方法
共纳入 937 名俄罗斯欧洲北部的本地居民（463 名男性和 474 名女性），年龄为 13-60 岁。采用免疫比浊法测定血浆中 apoE 的浓度。
结果
俄罗斯欧洲北部居民的血浆 apoE 水平较低。在 57.0%的男性和 59.2%的女性中检测到低于定义正常值的 apoE 浓度。男性和女性的平均血浆 apoE 水平无显著差异（2.80mg/dl 比 2.87mg/dl）。俄罗斯欧洲北部居民的血浆 apoE 浓度随年龄而变化。apoE 血浆水平在男性中从 13 岁到 21 岁，在女性中从 13 岁到 35 岁降低，然后在两性中均增加（p<0.001）。
结论
俄罗斯欧洲北部居民的血浆 apoE 水平变化范围向低值偏移。约一半的研究对象的 apoE 血浆水平低于正常值。
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