载脂蛋白B/载脂蛋白A-I比值作为血浆致动脉粥样硬化性的潜在标志物。
The apolipoprotein B/apolipoprotein A-I ratio as a potential marker of plasma atherogenicity.
作者信息
Kaneva Anastasiya M, Potolitsyna Natalya N, Bojko Evgeny R, Odland Jon Ø
机构信息
Institute of Physiology, Komi Science Center, Ural Branch of Russian Academy of Sciences, Pervomaiskaya Avenue 50, Syktyvkar 167982, Russia.
Faculty of Health Sciences, The Arctic University of Norway, 9037 Tromsø, Norway.
出版信息
Dis Markers. 2015;2015:591454. doi: 10.1155/2015/591454. Epub 2015 Mar 23.
BACKGROUND
The apolipoprotein (apo) B/apoA-I ratio represents the balance between apoB-rich atherogenic particles and apoA-I-rich antiatherogenic particles, and this ratio is considered to be a marker of cardiovascular risk. Although many studies have demonstrated the importance of the apoB/apoA-I ratio in predicting the presence or absence of cardiovascular disease, less is known about apoB/apoA-I ratio as a marker of plasma atherogenicity.
METHODS
A total of 157 normolipidemic men aged 20-59 years were included in the study. The plasma levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), apoA-I, apoB, and apoE were determined after a 12 h fasting period.
RESULTS
The median of the apoB/apoA-I ratio in the studied normolipidemic subjects was 0.52, with values ranging from 0.19 to 2.60. The percentage of subjects with the apoB/apoA-I ratio exceeding 0.9 (the accepted risk value of cardiovascular disease) was 19.1%. The subjects with apoB/apoA-I>0.9 were characterized by higher TG levels and atherogenic index of plasma (AIP) and lower values of ratio of low-density lipoprotein cholesterol (LDL-C) to apoB (LDL-C/apoB) and apoE levels compared with men with apoB/apoA-I<0.9.
CONCLUSION
Despite normolipidemia, the subjects with the unfavorable apoB/apoA-I ratio had more atherogenic lipid profile.
背景
载脂蛋白（apo）B/apoA-I 比值代表富含 apoB 的致动脉粥样硬化颗粒与富含 apoA-I 的抗动脉粥样硬化颗粒之间的平衡，该比值被认为是心血管风险的标志物。尽管许多研究已证明 apoB/apoA-I 比值在预测心血管疾病有无方面的重要性，但关于 apoB/apoA-I 比值作为血浆动脉粥样硬化性标志物的了解较少。
方法
本研究共纳入 157 名年龄在 20 - 59 岁的血脂正常男性。在禁食 12 小时后测定血浆总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、apoA-I、apoB 和 apoE 的水平。
结果
所研究的血脂正常受试者中 apoB/apoA-I 比值的中位数为 0.52，范围为 0.19 至 2.60。apoB/apoA-I 比值超过 0.9（心血管疾病公认风险值）的受试者比例为 19.1%。与 apoB/apoA-I<0.9 的男性相比，apoB/apoA-I>0.9 的受试者具有更高的 TG 水平和血浆动脉粥样硬化指数（AIP），以及更低的低密度脂蛋白胆固醇（LDL-C）与 apoB 的比值（LDL-C/apoB）和 apoE 水平。
结论
尽管血脂正常，但 apoB/apoA-I 比值不利的受试者具有更具动脉粥样硬化性的脂质谱。
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