Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, 1 Bowdoin Square, 6th Floor, Boston, MA 02114, USA.
Psychiatr Clin North Am. 2013 Mar;36(1):15-23. doi: 10.1016/j.psc.2012.12.002.
Over the past 2 decades, omega-3 fatty acids (n-3FAs) have been increasingly used and studied in the United States and worldwide for various medical and psychiatric indications. Numerous published clinical trials have examined applications of different n-3FA preparations, primarily in mood disorders but also in psychotic disorders, attention-deficit disorder, obsessive-compulsive disorder, and personality disorders. Focusing on clinical issues, this article reviews the impact of n-3FAs on these conditions and covers the relevant research, side effects, dosage guidelines, and drug interactions; clinicians should thus be able to better advise patients who are already taking n-3FAs or are interested in trying them.
在过去的 20 年中，ω-3 脂肪酸（n-3FAs）在美国和全球范围内越来越多地被用于各种医学和精神科适应症的治疗和研究。大量已发表的临床试验研究了不同 n-3FA 制剂的应用，主要是在情绪障碍方面，但也在精神病、注意力缺陷障碍、强迫症和人格障碍方面。本文主要关注临床问题，综述了 n-3FAs 对这些疾病的影响，并涵盖了相关研究、副作用、剂量指南和药物相互作用；因此，临床医生应该能够更好地为已经服用 n-3FAs 或有兴趣尝试的患者提供建议。
