Faustino Christine Grützmann, Passarelli Maria Cristina Guerra, Jacob-Filho Wilson
Geriatrics Outpatient Clinic, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Sao Paulo Med J. 2013;131(1):19-26. doi: 10.1590/s1516-31802013000100004.
CONTEXT AND OBJECTIVES In Brazil, few studies have investigated the prevalence of potentially inappropriate medications (PIMs) among elderly outpatients. This study aimed to determine the prevalence of PIMs prescribed for elderly outpatients, identify the PIMs most commonly involved, and investigate whether age, sex and number of medications are related to prescription of such medications. DESIGN AND SETTING Observational descriptive study developed in the Geriatrics Service of the Central Institute of Hospital das Clínicas (HC), Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil. METHODS Prescriptions issued to 1,270 elderly patients (≥ 60 years) were gathered from a database. These prescriptions had been written by geriatricians at a tertiary-level university hospital in São Paulo, Brazil, between February and May 2008. The prescriptions were divided according to sex and age group (60-69, 70-79 and ≥ 80). The Beers criteria were used to evaluate PIMs. RESULTS Most of the sample comprised women (77%) and the mean age was 80.1 years. The mean prevalence of PIM prescriptions was 26.9%. Female sex and number of medications prescribed were associated with prescription of PIMs. The chance of having a PIM prescription was lower among patients ≥ 70 years. CONCLUSION The greater prevalence of PIMs was correlated with female sex. The chance of having a PIM prescription was lower among patients ≥ 70 years and became greater with increasing numbers of medications prescribed (≥ 7).
背景与目的 在巴西，很少有研究调查老年门诊患者中潜在不适当用药（PIM）的患病率。本研究旨在确定老年门诊患者中开具的PIM的患病率，识别最常涉及的PIM，并调查年龄、性别和用药数量是否与这类药物的处方有关。
设计与地点 在巴西圣保罗市圣保罗大学医学院临床医院中央研究所老年医学科开展的观察性描述性研究。
方法 从一个数据库中收集了发给1270名老年患者（≥60岁）的处方。这些处方由巴西圣保罗一家三级大学医院的老年病科医生在2008年2月至5月期间开具。处方按性别和年龄组（60 - 69岁、70 - 79岁和≥80岁）进行划分。采用Beers标准评估PIM。
结果 样本中大多数为女性（77%），平均年龄为80.1岁。PIM处方的平均患病率为26.9%。女性性别和开具的用药数量与PIM处方有关。≥70岁的患者开具PIM处方的几率较低。
结论 PIM的较高患病率与女性性别相关。≥70岁的患者开具PIM处方的几率较低，且随着开具的用药数量增加（≥7种）而升高。
