Basu Rajit K, Wheeler Derek S
Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center.
Recent Pat Biomark. 2011;1(1):49-59.
Acute kidney injury (AKI) causes increased morbidity in critically ill children and damage to the kidney, a central mediator of homeostasis in the body, affects survival. The incidence of AKI in pediatrics is significant and despite alarming data, therapeutic interventions have failed to effect a meaningful difference in outcomes. In this review, we will discuss the epidemiology of AKI in pediatrics, treatment strategies attempted to date, experimental therapies targeting molecular patterns associated with AKI, and highlight the needed direction of AKI research and management. Prospective trials in pediatrics are needed to test the validity of diagnostic tools, to identify the point of most efficacious intervention, and to underscore the therapies that can be effective in the different downstream effects of AKI.
急性肾损伤（AKI）会增加危重症儿童的发病率，而作为体内稳态的核心调节器官，肾脏受损会影响生存。儿科AKI的发病率很高，尽管数据令人担忧，但治疗干预未能在结局方面产生有意义的差异。在本综述中，我们将讨论儿科AKI的流行病学、迄今为止尝试的治疗策略、针对与AKI相关分子模式的实验性疗法，并强调AKI研究和管理所需的方向。需要开展儿科前瞻性试验，以检验诊断工具的有效性，确定最有效的干预点，并强调可有效应对AKI不同下游效应的疗法。
