泰国糖尿病患者的吸烟与死亡情况：泰国糖尿病登记队列研究

Smoking and death in Thai diabetic patients: the Thailand Diabetic Registry cohort.

作者信息

Pratipanawatr Thongchai, Rawdaree Petch, Chetthakul Thanya, Bunnag Pongamorn, Ngarmukos Chardpraorn, Benjasuratwong Yupin, Leelawatana Rattana, Kosachunhanun Natapong, Plengvidhya Nattachet, Deerochanawong Chaicharn, Suwanwalaikorn Sompongse, Krittiyawong Sirinate, Mongkolsomlit Sirima, Komoltri Chulaluk

机构信息

Division of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol Universty, Bangkok, Thailand.

出版信息

J Med Assoc Thai. 2013 Mar;96(3):280-7.

PMID:23539929

Abstract

OBJECTIVE

To determine the impact of smoking and quit smoking on mortality rate.

MATERIAL AND METHOD

This prospective cohort was a three-year follow-up of Thai Diabetes Registry project that registered 9,370 diabetic patients from 10 diabetic clinics in tertiary medical centers in Bangkok and major provinces between April 2003 and February 2006.

RESULTS

The groups of 7,487 (80%), 1,315 (14%), and 568 (6%) patients were classified as non-smokers, ex-smokers, and current smokers. The crude death rate of ex-smokers (Hazard Ratio (HR) 1.52 (95% CI 1.19-1.95)) and current smokers (HR 1.55 (1.10-2.19)) were higher than death rate of non-smokers. After control for covariates, the HR comparing ex-smokers with non-smokers was not different (1.10 (0.81-1.50)), while the HR comparing current smokers with non-smokers remained statistical significant (1.74 (1.17-2.61)).

CONCLUSION

Smoking increases mortality rate in diabetic patients by about 74%. Quitting smoking decreased mortality rate to the same rate as of diabetic non-smokers.

摘要

目的

确定吸烟及戒烟对死亡率的影响。

材料与方法

这项前瞻性队列研究是对泰国糖尿病登记项目进行的为期三年的随访，该项目于2003年4月至2006年2月期间，在曼谷及主要省份的三级医疗中心的10家糖尿病诊所登记了9370名糖尿病患者。

结果

7487名（80%）、1315名（14%）和568名（6%）患者分别被归类为非吸烟者、已戒烟者和当前吸烟者。已戒烟者（风险比（HR）1.52（95%置信区间1.19 - 1.95））和当前吸烟者（HR 1.55（1.10 - 2.19））的粗死亡率高于非吸烟者。在对协变量进行控制后，已戒烟者与非吸烟者相比的HR无差异（1.10（0.81 - 1.50）），而当前吸烟者与非吸烟者相比的HR仍具有统计学意义（1.74（1.17 - 2.61））。