Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
Cell. 2013 Mar 28;153(1):56-69. doi: 10.1016/j.cell.2013.03.004.
Chemical modifications of histones and DNA, such as histone methylation, histone acetylation, and DNA methylation, play critical roles in epigenetic gene regulation. Many of the enzymes that add or remove such chemical modifications are known, or might be suspected, to be sensitive to changes in intracellular metabolism. This knowledge provides a conceptual foundation for understanding how mutations in the metabolic enzymes SDH, FH, and IDH can result in cancer and, more broadly, for how alterations in metabolism and nutrition might contribute to disease. Here, we review literature pertinent to hypothetical connections between metabolic and epigenetic states in eukaryotic cells.
组蛋白和 DNA 的化学修饰，如组蛋白甲基化、组蛋白乙酰化和 DNA 甲基化，在表观遗传基因调控中发挥着关键作用。许多添加或去除这些化学修饰的酶已经被发现，或者可能被怀疑，对细胞内代谢的变化敏感。这一知识为理解代谢酶 SDH、FH 和 IDH 的突变如何导致癌症，以及更广泛地，代谢和营养的改变如何导致疾病，提供了一个概念基础。在这里，我们回顾了与真核细胞中代谢和表观遗传状态之间的假设联系相关的文献。
