Sun Xiaoyan, Li Qingyang, Chen Bo
Gynecology, Dongguan Songshan Lake Central Hospital Affiliated to Guangdong Medical University, Dongguan, 523000, Guangdong, China.
Center for Reproductive Medicine, Dongguan Songshan Lake Central Hospital Affiliated to Guangdong Medical University, Dongguan, 523000, Guangdong, China.
Sci Rep. 2025 Jul 1;15(1):21751. doi: 10.1038/s41598-025-05622-9.
This study investigated the impact of mitochondrial dynamics on mouse preimplantation embryonic development and its underlying molecular mechanisms. Using pharmacological and genetic approaches, we demonstrated that balanced mitochondrial fusion and fission are essential for optimal embryonic development. Disruption of mitochondrial dynamics significantly impaired blastocyst formation, altered cell lineage allocation, and compromised energy metabolism. Our findings revealed that mitochondrial dynamics regulate gene expression through epigenetic modifications and influence cell survival through the modulation of apoptotic pathways. We also identified key metabolic intermediates and signaling pathways that mediate the effects of mitochondrial dynamics on embryonic development. These results provide new insights into the molecular mechanisms linking mitochondrial function to early embryonic development and suggest potential strategies for improving assisted reproductive technologies.
本研究调查了线粒体动力学对小鼠植入前胚胎发育的影响及其潜在分子机制。通过药理学和遗传学方法，我们证明了平衡的线粒体融合和分裂对于最佳胚胎发育至关重要。线粒体动力学的破坏显著损害囊胚形成，改变细胞谱系分配，并损害能量代谢。我们的研究结果表明，线粒体动力学通过表观遗传修饰调节基因表达，并通过调节凋亡途径影响细胞存活。我们还确定了介导线粒体动力学对胚胎发育影响的关键代谢中间体和信号通路。这些结果为将线粒体功能与早期胚胎发育联系起来的分子机制提供了新见解，并提出了改善辅助生殖技术的潜在策略。
