Department of Medicine, Division of Cardiology, Jefferson Heart Institute, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Semin Oncol. 2013 Apr;40(2):156-67. doi: 10.1053/j.seminoncol.2013.01.004.
Cancer chemotherapy has improved over the years with the advent of newer agents, including more targeted chemotherapeutic drugs, resulting in better patient survival. However, with continued use and patient exposure to these drugs, important cardiovascular adverse effects are becoming realized, such as left ventricular dysfunction and heart failure, myocardial ischemia, hypertension, arrhythmias, and pulmonary arterial hypertension. In this article, we review the most common cardiovascular toxicities and their related pathophysiology that occur with the use of these agents.
随着新型药物（包括更具针对性的化疗药物）的出现，癌症化疗在这些年得到了改善，这使得患者的生存率得到了提高。然而，随着这些药物的持续使用和患者接触，重要的心血管不良事件也逐渐显现，如左心室功能障碍和心力衰竭、心肌缺血、高血压、心律失常和肺动脉高压。本文综述了这些药物使用过程中常见的心血管毒性及其相关病理生理学。
