Lange H, Stephan H, Rieke H, Kellermann M, Sonntag H, Bircher J
Department of Clinical Anaesthesiology, University of Göttingen, F.R.G.
Br J Anaesth. 1990 May;64(5):563-70. doi: 10.1093/bja/64.5.563.
In order to clarify the relative contribution of the liver to the short term disposition of propofol, hepatic blood flow was measured during induction of anaesthesia with an i.v. bolus dose of propofol 2 mg kg-1. Total clearance of the drug was 2390 (SD 340) ml min-1, hepatic extraction 82% and hepatic clearance 1060 (260) ml min-1. During the 60-min period of observation, hepatic extraction of propofol increased from 79% to 92%. It is concluded that, within 1 h, only 44% of the administered dose is removed by the liver. Consequently, drug accumulation may occur with repeated dosing or infusion of propofol. The increase in extraction results presumably from slow release of propofol from the soy-bean emulsion.
为了阐明肝脏对丙泊酚短期处置的相对贡献，在静脉注射2mg/kg丙泊酚诱导麻醉期间测量肝血流量。该药物的总清除率为2390（标准差340）ml/min，肝提取率为82%，肝清除率为1060（260）ml/min。在60分钟的观察期内，丙泊酚的肝提取率从79%增加到92%。结论是，在1小时内，肝脏仅清除44%的给药剂量。因此，重复给药或输注丙泊酚可能会导致药物蓄积。提取率的增加可能是由于丙泊酚从大豆乳剂中缓慢释放所致。
