Shun-Shin G A, Ratcliffe P, Bron A J, Brown N P, Sparrow J M
Clinical Cataract Research Unit, Nuffield Laboratory of Ophthalmology, University of Oxford.
Br J Ophthalmol. 1990 May;74(5):267-71. doi: 10.1136/bjo.74.5.267.
A single masked observer examined 55 non-diabetic patients chosen randomly from a population of patients who had undergone renal transplant. The mean age was 41 years and mean time from transplant was 4.4 years (1-10 years). Fourteen patients were found to have a posterior subcapsular cataract (PSC). The axial thickness of the right lens of the renal transplant population, even in the presence of a PSC, was significantly larger than in a control population of 99 patients with clear lenses. The PSC of renal transplantation is readily distinguished from age related PSC because the opacity lies in the superficial cortex at a depth proportional to time from transplant and the lens maintains a normal anterior clear zone. It is proposed that this type of cataract be called 'recovering' PSC. It is concluded that the cataractogenic insult occurs mainly during the peritransplant period. Maintenance doses of immunosuppressives or steroids are therefore probably not cataractogenic.
一名蒙面观察者对55名从接受肾移植的患者群体中随机挑选出的非糖尿病患者进行了检查。平均年龄为41岁，移植后的平均时间为4.4年（1至10年）。发现14名患者患有后囊下白内障（PSC）。肾移植患者群体右晶状体的轴厚，即使在存在PSC的情况下，也明显大于99名晶状体清晰的对照患者群体。肾移植的PSC很容易与年龄相关性PSC区分开来，因为混浊位于浅表皮质，深度与移植后的时间成正比，并且晶状体保持正常的前部透明区。建议将这种类型的白内障称为“恢复性”PSC。得出的结论是，致白内障损伤主要发生在移植周围期。因此，免疫抑制剂或类固醇的维持剂量可能不会导致白内障。
