Nasir Arwa, Al Tatari Hosam, Hamdan Mohamed A
Children's Hospital and Medical Center, Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska, USA;
Paediatr Child Health. 2012 Apr;17(4):201-4. doi: 10.1093/pch/17.4.201.
Kawasaki disease (KD) is an inflammatory condition of unknown etiology that affects children, with a peak incidence in the second year of life. KD is uncommon in the first year of life and is rare in the newborn period. The present report describes three newborn infants who were admitted to hospital with fever and nearly identical clinical features of generalized inflammation. The presentations did not meet the criteria for KD; however, all three patients responded promptly and completely to intravenous immunoglobulin treatment. Specifically, the association of these presentations with very high levels of serum ferritin is reported. The authors propose that this clinical syndrome represents a variant of KD, and that serum ferritin level may be a useful marker in diagnosing KD and its variants. Additionally, the association of this clinical picture with very high serum ferritin levels raises the possibility of a link with hemophagocytic lymphohistiocytosis.
川崎病（KD）是一种病因不明的炎症性疾病，主要影响儿童，发病高峰在出生后第二年。KD在出生后第一年并不常见，在新生儿期则极为罕见。本报告描述了三名因发热入院的新生儿，他们具有几乎相同的全身炎症临床特征。这些表现不符合KD的诊断标准；然而，所有三名患者对静脉注射免疫球蛋白治疗均迅速且完全起效。具体而言，报告了这些表现与血清铁蛋白水平极高之间的关联。作者提出，这种临床综合征代表了KD的一种变体，血清铁蛋白水平可能是诊断KD及其变体的有用标志物。此外，这种临床症状与血清铁蛋白水平极高之间的关联增加了与噬血细胞性淋巴组织细胞增生症相关联的可能性。
