Qiu Zhen, Liu Hui Hui, Fan Guo Zhen, Chen Wei Xia, Hu Peng
Department of Pediatrics, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
Arch Med Sci. 2021 Dec 8;18(1):267-274. doi: 10.5114/aoms/144293. eCollection 2022.
Serum ferritin (SF) is an acute-phase reactant in inflammatory diseases. Our aim was to analyze the clinical implications of SF in Kawasaki disease (KD).
244 KD children were divided into 6 subgroups. SF, inflammatory mediators and blood cell counts were detected.
(1) SF dramatically increased in the acute phase of KD and maintained after IVIG therapy; (2) SF increased in IVIG-nonresponsive KD patients (AUC = 0.705; sensitivity: 57.10%; specificity: 82.90%); SF positively correlated with the internal diameter of the coronary artery (AUC = 0.603; sensitivity: 92.30%; specificity: 37.70%); (3) SF increased in 4 patients with the macrophage activation syndrome (MAS)/MAS tendency (979.03 ±474.19 μg/l).
SF is implied to be a helpful biomarker for forecasting IVIG-nonresponsive KD, coronary artery abnormalities (CAAs) and MAS tendency.
血清铁蛋白（SF）是炎症性疾病中的一种急性期反应物。我们的目的是分析SF在川崎病（KD）中的临床意义。
将244例KD患儿分为6个亚组。检测SF、炎症介质和血细胞计数。
（1）KD急性期SF显著升高，静脉注射免疫球蛋白（IVIG）治疗后仍维持升高；（2）IVIG无反应性KD患者SF升高（曲线下面积[AUC]=0.705；敏感性：57.10%；特异性：82.90%）；SF与冠状动脉内径呈正相关（AUC=0.603；敏感性：92.30%；特异性：37.70%）；（3）4例巨噬细胞活化综合征（MAS）/有MAS倾向的患者SF升高（979.03±474.19μg/l）。
SF被认为是预测IVIG无反应性KD、冠状动脉异常（CAA）和MAS倾向的有用生物标志物。
