Sección de Inmunología, Instituto de Medicina Tropical, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela.
Epidemiol Infect. 2014 Jan;142(1):156-62. doi: 10.1017/S0950268813000757. Epub 2013 Apr 2.
Trypanosoma cruzi I, a discrete typing unit (DTU) found in human infections in Venezuela and other countries of the northern region of South America and in Central America, has been recently classified into five intra-DTU genotypes (Ia, Ib, Ic, Id, Ie) based on sequence polymorphisms found in the spliced leader intergenic region. In this paper we report the genotype identification of T. cruzi human isolates from one outbreak of acute orally acquired Chagas disease that occurred in a non-endemic region of Venezuela and from T. cruzi triatomine and rat isolates captured at a guava juice preparation site which was identified as the presumptive source of infection. The genotyping of all these isolates as TcId supports the view of a common source of infection in this oral Chagas disease outbreak through the ingestion of guava juice. Implications for clinical manifestations and dynamics of transmission cycles are discussed.
克氏锥虫 I 型，一种离散型分型单元（DTU），见于委内瑞拉和南美洲北部及中美洲其他国家的人类感染，最近根据在拼接领导基因间区发现的序列多态性，被分为五个内 DTU 基因型（Ia、Ib、Ic、Id、Ie）。本文报告了委内瑞拉非流行区一起急性经口感染克氏锥虫病例和在番石榴果汁制备点捕获的锥蝽和鼠分离株的基因型鉴定，该制备点被认为是感染的假定来源。所有这些分离株均为 TcId 基因型，支持通过摄入番石榴果汁导致这起经口感染克氏锥虫病暴发的共同感染源假说。讨论了对临床表现和传播循环动力学的影响。
