Department DiSSPAPA, University of Naples, Portici, Naples, Italy.
Infect Immun. 2013 Jun;81(6):2139-44. doi: 10.1128/IAI.01398-12. Epub 2013 Apr 1.
The study demonstrates that in cattle, animals heterozygous at the MyD88 A625C polymorphic marker have a 5-fold reduced risk for active pulmonary tuberculosis (odds ratio [OR] = 0.19; P = 6 × 10(-12)). The reduced risk, however, does not extend to animals with latent pulmonary tuberculosis (OR = 0.83; P = 0.40). Heterozygosity at the A625C single nucleotide polymorphism is associated with intermediate levels of tumor necrosis factor alpha, gamma interferon, and nitric oxide synthase (NOS). Accordingly, deficiency as well as overexpression of proinflammatory cytokines or NOS favor tuberculosis, while heterozygosity provides the animals with the optimal level of inflammation.
研究表明，在牛中，MyD88 A625C 多态性标记物杂合的动物患活动性肺结核的风险降低了 5 倍（比值比 [OR] = 0.19；P = 6×10(-12)）。然而，这种风险降低并不适用于患有潜伏性肺结核的动物（OR = 0.83；P = 0.40）。A625C 单核苷酸多态性的杂合性与肿瘤坏死因子-α、γ干扰素和一氧化氮合酶（NOS）的中间水平相关。因此，促炎细胞因子或 NOS 的缺乏以及过表达都有利于结核病，而杂合性为动物提供了最佳的炎症水平。
