Departments of Biochemistry, University of Pretoria, Hatfield, South Africa.
Antimicrob Agents Chemother. 2013 Jun;57(6):2874-7. doi: 10.1128/AAC.00106-13. Epub 2013 Apr 1.
Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite Plasmodium falciparum, with 50% inhibitory concentrations (IC50s) in the nM to μM range. The compounds are taken up into the intraerythrocytic parasite, where they arrest the parasite cell cycle. Both the anthracene and polyamine components of the conjugates play a role in their antiplasmodial effect.
蒽胺缀合物抑制红细胞内人类疟原虫恶性疟原虫的体外增殖，其 50%抑制浓度（IC50）在纳摩尔至微摩尔范围内。这些化合物被摄取到红细胞内寄生虫中，在那里它们阻止寄生虫细胞周期。缀合物的蒽和多胺成分都在其抗疟原虫作用中发挥作用。
