Medicines for Malaria Venture, Route de Pré-Bois 20, PO Box 1826, 1215 Geneva 15, Switzerland.
Future Med Chem. 2011 Sep;3(11):1401-12. doi: 10.4155/fmc.11.91.
Malaria is one of the most devastating diseases in the world, affecting almost 225 million people a year, and causing over 780,000 deaths, most of which are children under the age of 5 years. Following the recent call for the eradication of the disease, supported by the WHO, there has been increasing investment into antimalarial drug-discovery projects. These activities are aimed at generating the next generation of molecules focused on the treatment and transmission-blocking of Plasmodium falciparum and Plasmodium vivax endo- and exo-erythrocytic stages of the parasite. This article summarizes the current top-level thinking regarding the prosecution of such endeavors and the disease-specific considerations in project planning.
疟疾是世界上最具破坏性的疾病之一，每年影响近 2.25 亿人，并导致超过 78 万人死亡，其中大多数是 5 岁以下的儿童。最近，世界卫生组织呼吁消灭这种疾病，这引起了对抗疟药物发现项目的投资增加。这些活动旨在生成新一代分子，专注于治疗和阻断疟原虫和恶性疟原虫的内、外红细胞期的寄生虫。本文总结了目前在这类努力和项目规划中的疾病特异性考虑方面的最高级别的思考。
