McKeever W F, Rich D A
Northern Arizona University.
Cortex. 1990 Mar;26(1):33-40. doi: 10.1016/s0010-9452(13)80073-1.
The Geschwind-Behan hypothesis that immune disorder (IMD) is more common among left than among right handed persons was tested in a sample of 3080 college students. Subjects indicated, for each of a list of IMDs, whether they: (1) had no reason to believe they had the disorder; (2) thought they might have the disorder; (3) had the disorder diagnosed by a physician; or (4) had had a disorder diagnosed and treated by a physician. Females reported significantly more IMDs than did males. Among females, the distribution of responses across the four response categories was not different for left and right handers, but IMD was significantly higher among left handed females when only the extreme categories were considered. Among males, no handedness effect was seen across the four categories, nor when only the extreme categories were considered. Laterality quotients, from the Edinburgh Handedness Inventory, were unrelated to IMD reports in both sexes. Results provide no real support for the Geschwind-Behan hypothesis. Even in the case of the extreme categories of IMD reports of females, the association of left handedness (for writing) and IMD accounts for only three-tenths of one percent of the variance.
在一项针对3080名大学生的样本中，对 Geschwind-Behan 假说（即免疫紊乱（IMD）在左利手人群中比在右利手人群中更常见）进行了测试。受试者针对一系列免疫紊乱情况，表明他们：（1）没有理由相信自己患有该疾病；（2）认为自己可能患有该疾病；（3）已由医生诊断患有该疾病；或（4）已由医生诊断并治疗过该疾病。女性报告的免疫紊乱情况显著多于男性。在女性中，左利手和右利手在四个回答类别中的分布没有差异，但仅考虑极端类别时，左利手女性的免疫紊乱情况显著更高。在男性中，在四个类别中均未观察到利手效应，仅考虑极端类别时也未观察到。来自爱丁堡利手量表的利手商数与两性的免疫紊乱报告均无关。结果并未真正支持 Geschwind-Behan 假说。即使在女性免疫紊乱报告的极端类别情况下，左利手（用于书写）与免疫紊乱之间的关联仅占变异的千分之三。
