Gardiman M P, Fassan M, Nozza P, Orvieto E, Garrè M L, Milanaccio C, Severino M, Perilongo G, Giangaspero F
Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy.
Pathologica. 2012 Dec;104(6):428-31.
Glioneuronal tumours are a group of primary brain neoplasms of relatively recent acquisition in the World Health Organization (WHO) Classification of the Central Nervous System tumours. In diagnostic practice it is still possible to encounter glioneuronal tumours that cannot be placed into any of the well-defined WHO categories despite a growing list of entities. We have recently published four paediatric cases of diffuse leptomeningeal tumours that cannot be easily classified in the currently used CNS WHO classification, but which have histological and immunohistochemical criteria to be considered as glioneuronal tumours. The clinical, neuroradiological and pathological long-term follow-up of an unusual diffuse leptomeningeal glioneuronal tumour is presented herein.
神经胶质神经元肿瘤是世界卫生组织（WHO）中枢神经系统肿瘤分类中相对较新纳入的一组原发性脑肿瘤。在诊断实践中，尽管明确的肿瘤类型越来越多，但仍有可能遇到无法归入任何一种明确的WHO类别的神经胶质神经元肿瘤。我们最近发表了4例儿童弥漫性软脑膜肿瘤病例，这些肿瘤难以用目前使用的WHO中枢神经系统分类进行分类，但具有组织学和免疫组化标准，可被视为神经胶质神经元肿瘤。本文介绍了一例罕见的弥漫性软脑膜神经胶质神经元肿瘤的临床、神经放射学和病理学长期随访情况。
