Jiang Yun, Chen Juan, He Jing, Pei Ao, Zhang Jinsong, Liu Yinhong
Department of Neurology, Beijing Hospital, National Center of Gerontology, Beijing, China.
Department of Radiology, Beijing Hospital, National Center of Gerontology, Beijing, China.
Front Oncol. 2017 Oct 9;7:240. doi: 10.3389/fonc.2017.00240. eCollection 2017.
Primary diffuse leptomeningeal gliomatosis (PDLG) is a rare and fatal disease with no special clinical manifestations. Here, we report the dynamic brain magnetic resonance imaging (MRI) changes in a 30-year-old female PDLG patient over a 10-month period. MRI showed aggressive dilation of the subarachnoid space and the ventricular system, numerous encapsulated cysts in the subarachnoid space and the dilated cerebral sulci, diffuse reticulated or focal nodular enhancement in the subarachnoid space, as well as overall enhancement in the cystic walls. In addition to the aforementioned PDLG pathological findings, MRI also revealed non-contrasted solid lesions and a contrasted cyst-like lesion in the paraventricular areas. The dynamic and multiform neuroradiological changes help us to understand the pathological process of PDLG. Of particular interest is the discovery that parenchymal infiltration can occur in PDLG.
原发性弥漫性软脑膜胶质瘤病（PDLG）是一种罕见的致命疾病，无特殊临床表现。在此，我们报告一名30岁女性PDLG患者在10个月期间的动态脑磁共振成像（MRI）变化。MRI显示蛛网膜下腔和脑室系统进行性扩张，蛛网膜下腔和扩张的脑沟内有大量包膜囊肿，蛛网膜下腔弥漫性网状或局灶性结节状强化，以及囊肿壁整体强化。除上述PDLG病理表现外，MRI还显示脑室旁区域有非强化实性病变和强化囊肿样病变。动态和多样的神经放射学变化有助于我们了解PDLG的病理过程。特别值得关注的是发现PDLG可发生实质浸润。
