Pusiol T, Zorzi M G, Morichetti D
Institute of Anatomic Pathology, Rovereto Hospital, Rovereto, Italy.
Pathologica. 2012 Dec;104(6):449-51.
The classification of ovarian fibromatous tumours with high mitotic activity is controversial.
The first case was an 18 x 17 x 10 cm left ovarian fibromatous tumour with 17 mitoses/10 HPF detected in a 44-year-old woman. The second case consisted of a 4 x 2.5 x 2 and a 2.5 x 2.5 x 2 cm fibrmatous tumours found, respectively, in the left and right ovaries of a 67-year-old woman. The mitotic count varied from 4 to 6/10 HPF.
Prat & Scully reported that mitotic activity was the most important factor in diagnosing fibrosarcomas, and that cellular pleomorphism was not reliable. Irving et al. suggested that cellular fibromatous neoplasms with bland nuclear features and mitotic count of > or = 4 MFs/10 HPFs should be considered mitotically-active cellular fibromas rather than fibrosarcomas. We propose the term 'fibromatous tumours of uncertain biological potential' when an average mitotic count of 4 or more per 10 HPFs are found and nuclear atypia and necrosis are absent.
有丝分裂活性高的卵巢纤维瘤样肿瘤的分类存在争议。
第一例为一名44岁女性，左卵巢纤维瘤样肿瘤，大小为18×17×10 cm，每10个高倍视野中有17个有丝分裂象。第二例为一名67岁女性，分别在左、右卵巢发现一个4×2.5×2 cm和一个2.5×2.5×2 cm的纤维瘤样肿瘤，有丝分裂计数为4至6/10个高倍视野。
普拉特和斯库利报告称，有丝分裂活性是诊断纤维肉瘤的最重要因素，而细胞多形性不可靠。欧文等人建议，细胞核特征温和且有丝分裂计数≥4个有丝分裂象/10个高倍视野的细胞性纤维瘤样肿瘤应被视为有丝分裂活性的细胞性纤维瘤而非纤维肉瘤。当每10个高倍视野平均有丝分裂计数为4个或更多且无细胞核异型性和坏死时，我们建议使用“生物学潜能不确定的纤维瘤样肿瘤”这一术语。
