Kuntz L, Fonteneau P, Loor F
Laboratoire d'Immunologie, Centre de Recherches Pharmaceutiques, Université Louis Pasteur, Illkirch, France.
Immunol Lett. 1990 May;24(2):97-101. doi: 10.1016/0165-2478(90)90018-l.
The "viable motheaten" (mev) mutation in the C57BL/6 (B6) mouse causes in mev-homozygous B6 mice a rapidly progressing and fatal autoimmune syndrome, combined with a generalized immunodeficiency. Serological analyses of a large number of mev/mev individual mice revealed profound abnormalities of the levels of various spontaneously occurring, natural antibodies and of the levels and distribution of the different classes of immunoglobulins, some common to all mev/mev mice and some specific to individual mice. Although very high serum IgM levels (70X the normal B6 mouse serum level) and high anti-ssDNA titers are common features, the increases in the other immunoglobulin isotypes are not so marked (4.7X for IgG3, 2.7X for IgA, 1.6X for IgG1 and IgG2b, and even 0.6X for IgG2a), and the occurrence of other natural antibody specificities shows more individual variability.
C57BL/6（B6）小鼠中的“存活斑驳”（mev）突变在纯合子mev B6小鼠中引发一种迅速进展且致命的自身免疫综合征，并伴有全身性免疫缺陷。对大量mev/mev个体小鼠的血清学分析显示，各种自发产生的天然抗体水平以及不同类别的免疫球蛋白水平和分布存在严重异常，其中一些是所有mev/mev小鼠共有的，一些是个别小鼠特有的。尽管血清IgM水平极高（是正常B6小鼠血清水平的70倍）和抗单链DNA滴度高是常见特征，但其他免疫球蛋白同种型的增加并不那么显著（IgG3为4.7倍，IgA为2.7倍，IgG1和IgG2b为1.6倍，甚至IgG2a为0.6倍），并且其他天然抗体特异性的出现显示出更多个体差异。
