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Partial expression of the viable motheaten (mev) mutation in the heterozygous state: abnormal levels of serum immunoglobulins and natural anti-ssDNA antibodies.

作者信息

Kuntz L, Fonteneau P, Loor F

机构信息

Laboratoire d'Immunologie, Université Louis Pasteur, (Strasbourg 1), Illkirch, France.

出版信息

J Autoimmun. 1990 Jun;3(3):329-35. doi: 10.1016/0896-8411(90)90151-h.

DOI:10.1016/0896-8411(90)90151-h
PMID:2118764
Abstract

The 'viable motheaten' (mev) mutation in the C57BL/6 (B6) mouse causes a rapidly progressive and fatal autoimmune syndrome in mev-homozygous B6 mice, combined with generalized immunodeficiency, whereas the mev-heterozygous B6 mice look phenotypically normal. However, serological analyses of the levels of some spontaneously occurring, natural antibodies and of the levels and distribution of the different classes of immunoglobulins revealed mild but evident dysregulation of the natural humoral immunity of +/mev individuals.

摘要

相似文献

1
Partial expression of the viable motheaten (mev) mutation in the heterozygous state: abnormal levels of serum immunoglobulins and natural anti-ssDNA antibodies.
J Autoimmun. 1990 Jun;3(3):329-35. doi: 10.1016/0896-8411(90)90151-h.
2
Common and individual features of the humoral immunity dysregulation of mice homozygous at the viable motheaten (mev) mutation.存活型食母生（mev）突变纯合小鼠体液免疫调节的共同特征和个体特征。
Immunol Lett. 1990 May;24(2):97-101. doi: 10.1016/0165-2478(90)90018-l.
3
Adoptive transfer of viable motheaten (mev) humoral autoimmunity: IgM to IgG switch of the hyperglobulinaemia in nude, beige recipient mice.有活力的母系自身免疫病（mev）的过继转移：裸鼠、米色受体小鼠中高球蛋白血症的IgM向IgG转换
Immunology. 1990 Nov;71(3):341-6.
4
Serological abnormalities induced by engraftment of viable motheaten hematopoietic cells in nude beige recipients.
Autoimmunity. 1995;20(1):25-32. doi: 10.3109/08916939508993336.
5
Adoptive transfer of viable motheaten humoral autoimmunity in cyclophosphamide-immunodepressed beige recipient mice.在环磷酰胺免疫抑制的米色受体小鼠中进行有活力的母系自身免疫的过继转移。
Immunology. 1990 Aug;70(4):520-6.
6
Serum immunoglobulin isotype profile of viable and non viable lymphoid cell chimaeras made with nude athymic lpr (lymphoproliferation) mouse recipients.用无胸腺裸鼠lpr（淋巴细胞增殖）小鼠受体制作的存活和非存活淋巴细胞嵌合体的血清免疫球蛋白同种型谱。
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7
Skewed VH and V kappa gene family expression and pairing occurs among B lymphocytes in autoimmune motheaten mice.在自身免疫性斑驳病小鼠的B淋巴细胞中，VH和Vk基因家族表达及配对出现偏态。
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The Yaa mutation induces the development of autoimmunity in mice heterozygous for the gld (generalized lymphadenopathy disease) mutation.Yaa突变会在携带gld（全身性淋巴结病）突变的杂合小鼠中诱发自身免疫性疾病的发展。
Cell Immunol. 1994 Jul;156(2):519-28. doi: 10.1006/cimm.1994.1195.
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Interactions of B6 wild and B6 gld cells engrafted within athymic nude beige recipients.植入无胸腺裸鼠米色受体体内的B6野生型细胞和B6 gld细胞之间的相互作用。
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Partial expression of the lpr locus in the heterozygous state: presence of autoantibodies.lpr基因座在杂合状态下的部分表达：自身抗体的存在。
Immunology. 1988 May;64(1):31-6.

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