Alcantara Marice B, Dass Crispin R
School of Biomedical and Health Sciences, Victoria University, St Albans.
Cell Physiol Biochem. 2013;31(4-5):487-94. doi: 10.1159/000350069. Epub 2012 Mar 22.
The balance of endogenous angiogenic factors in the body is responsible for the homeostatic control of angiogenesis during normal physiological circumstances, with the disruption of this fragile balance leading to pathologic angiogenic events such as those involved in cancer progression. This review focuses regulation of the pro-angiogenic factors membrane type-1 matrix metalloproteinase (MT1-MMP) and matrix metalloproteinase-2 (MMP-2) by the anti-angiogenic factor pigment epithelium-derived factor (PEDF) in the contexts of angiogenesis, cancer cell proliferation and metastasis. Understanding the role of PEDF in the regulation of MT1-MMP and MMP-2 as it pertains to cancer control is important in order to understand whether and how such associations provide a novel target for cancer therapy.
在正常生理情况下，体内内源性血管生成因子的平衡负责血管生成的稳态控制，而这种脆弱平衡的破坏会导致病理性血管生成事件，如那些与癌症进展相关的事件。本综述聚焦于抗血管生成因子色素上皮衍生因子（PEDF）在血管生成、癌细胞增殖和转移背景下对促血管生成因子膜型-1基质金属蛋白酶（MT1-MMP）和基质金属蛋白酶-2（MMP-2）的调控。了解PEDF在调控MT1-MMP和MMP-2中与癌症控制相关的作用，对于理解这种关联是否以及如何为癌症治疗提供新靶点至关重要。
