Curtin Medical School, Curtin University, Bentley 6102, Australia; Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Curtin Medical School, Curtin University, Bentley 6102, Australia; Curtin Health Innovation Research Institute, Bentley 6102, Australia.
Biochem Pharmacol. 2021 Nov;193:114787. doi: 10.1016/j.bcp.2021.114787. Epub 2021 Sep 24.
Pigment epithelium-derived factor (PEDF) is a non-inhibitory member of the serpin (serine protease inhibitor) family and is a well-known potent anti-tumor factor in a variety of cancers. It has been ascertained that PEDF regulates multiple metastatic processes through various plausible mechanisms, including inhibiting angiogenesis, inducing apoptosis, stimulating extracellular matrix (ECM) degradation, and suppressing the epithelial-to-mesenchymal transition (EMT) process. Although PEDF has been recognized as an anti-metastatic marker in most studies, its role remains controversial with conflicting reports of PEDF as a metastatic marker. The emerging insights into the mechanism(s) of PEDF in tumor progression and its therapeutic effects are discussed systematically in this review, aiming to improve our understanding in the context of metastasis and drug development.
色素上皮衍生因子（PEDF）是丝氨酸蛋白酶抑制剂（serpin）家族的非抑制性成员，是多种癌症中一种著名的强效抗肿瘤因子。已经确定 PEDF 通过多种合理的机制调节多种转移过程，包括抑制血管生成、诱导细胞凋亡、刺激细胞外基质（ECM）降解和抑制上皮-间充质转化（EMT）过程。尽管 PEDF 在大多数研究中被认为是一种抗转移标志物，但它的作用仍然存在争议，有报道称 PEDF 是一种转移标志物。本综述系统地讨论了 PEDF 在肿瘤进展中的作用机制及其治疗效果，旨在提高我们在转移和药物开发背景下的认识。
