抗θ（Thy-1）抗体与苯丁酸氮芥联合应用的体外细胞毒性。
In vitro cytotoxicity of anti-theta (Thy-1) antibodies combined with chlorambucil.
作者信息
O'Neill G J, Pearson B A, Davies D A
出版信息
Immunology. 1975 Feb;28(2):323-9.
Abstract
Two methods are described for linking chlorambucil to antibodies. At low pH an association is formed which is not stable under physiological conditions and the cytotoxicity is the result of the independent action of chlorambucil and antibody. At pH 8 a more stable linkage is formed and this complex shows specific toxicity for cells carrying the appropriate antigen. Uncombined chlorambucil and antibody are more cytotoxic that chlorambucil alone, especially if the cells are exposed first to the chlorambucil.
摘要
本文描述了两种将苯丁酸氮芥与抗体连接的方法。在低pH值下会形成一种在生理条件下不稳定的结合物，细胞毒性是苯丁酸氮芥和抗体独立作用的结果。在pH 8时会形成更稳定的连接，这种复合物对携带相应抗原的细胞显示出特异性毒性。未结合的苯丁酸氮芥和抗体比单独的苯丁酸氮芥细胞毒性更强，尤其是当细胞先接触苯丁酸氮芥时。
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