甲状腺功能亢进症患儿和青少年的性激素结合球蛋白水平升高。

Increased sex hormone-binding globulin levels in children and adolescents with thyrotoxicosis.

机构信息

Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

出版信息

Horm Res Paediatr. 2013;79:157-61. doi: 10.1159/000348837. Epub 2013 Mar 27.

DOI:10.1159/000348837

PMID:23548728

Abstract

BACKGROUND

Thyrotoxicosis is a rare condition in pediatric patients, and optimal treatment can be difficult to achieve in some children. To our knowledge, no studies have evaluated sex hormone-binding globulin (SHBG) levels in hyperthyroid children and adolescents in relation to age- and gender-related normative data.

METHODS

SHBG serum levels were determined before and after 4 months of antithyroid therapy (ATT) in 10 children and adolescents with Graves' disease. A total of 903 healthy children and adolescents served as controls.

RESULTS

Serum SHBG levels were elevated (>2 SD) at diagnosis in all hyperthyroid children but normalized rapidly following ATT. At diagnosis, median SHBG was +2.51 SD (interquartile range 2.20-3.27) compared to healthy children without thyroid illness, and it declined significantly during ATT (-0.16 SD, -0.66 to 1.64; p < 0.05).

CONCLUSION

This is the first study to demonstrate that serum SHBG levels are markedly increased in children with Graves' disease, and we suggest that SHBG may be an additional marker of thyroid hormone action in children, as has been shown in adults.

摘要

背景

甲状腺毒症在儿科患者中较为罕见，某些儿童的最佳治疗方法难以实现。据我们所知，尚无研究评估过与年龄和性别相关的正常数据中，甲状腺功能亢进的儿童和青少年的性激素结合球蛋白 (SHBG) 水平。

方法

10 名格雷夫斯病儿童和青少年在接受抗甲状腺治疗 (ATT) 4 个月前后，测定了血清 SHBG 水平。共有 903 名健康的儿童和青少年作为对照组。

结果

所有甲状腺功能亢进的儿童的血清 SHBG 水平在诊断时均升高（>2 个标准差），但在 ATT 后迅速恢复正常。在诊断时，中位 SHBG 比无甲状腺疾病的健康儿童高出+2.51 个标准差（四分位间距 2.20-3.27），并且在 ATT 期间显著下降（-0.16 个标准差，-0.66 至 1.64；p<0.05）。