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甲状腺手术中低血压的危险因素。

Risk factors for intraoperative hypotension during thyroid surgery.

机构信息

Faculty of Medicine, University of Belgrade, Belgrade, Serbia and Centre for Endocrine Surgery, Clinical Centre of Serbia, Belgrade, Serbia.

出版信息

Med Sci Monit. 2013 Apr 3;19:236-41. doi: 10.12659/MSM.883869.

Abstract

BACKGROUND

Hypotension is a common adverse effect of IV anaesthetics, especially during the induction of anaesthesia. The aim of our study was to determine the incidence and risk factors for intraoperative hypotension (IOH) in thyroid surgery, as well as to determine whether and to what extent IOH affects the occurrence of postoperative hypotension.

MATERIAL AND METHODS

The study included 1252 euthyroid patients, ASA 2 and ASA 3 status (American Society of Anesthesiologists physical status classification), who had thyroid surgery between 2007 and 2011. IOH was defined as a decrease in systolic blood pressure of >20% of baseline values. We studied the influence of demographic characteristics (sex, age, body mass index-BMI), comorbidity, type and duration of surgery, and anaesthesia on the occurrence of IOH. Univariate and multivariate logistic regression were used to determine predictors of occurrence of IOH.

RESULTS

IOH was registered in 6.5% of patients. The most common operation was thyroidectomy. Patients with IOH were younger, had lower BMI, and significantly less often had hypertension as a coexisting disease. The multivariate regression model identified BMI and the absence of hypertension as a coexisting disease, and as independent predictors of occurrence of IOH. Significantly more patients with IOH had postoperative hypotension (9.9% vs. 2.4%, p=0.000).

CONCLUSIONS

IOH is common, even during operations of short duration and with minimal bleeding. It is necessary to pay special attention to these patients, given that many of these patients remained hypotensive during the postoperative period.

摘要

背景

低血压是静脉麻醉的常见不良反应,尤其是在麻醉诱导期间。我们的研究旨在确定甲状腺手术中术中低血压(IOH)的发生率和危险因素,以及 IOH 是否以及在何种程度上影响术后低血压的发生。

材料和方法

该研究纳入了 1252 例甲状腺功能正常的 ASA 2 和 ASA 3 患者(美国麻醉医师协会身体状况分类),他们在 2007 年至 2011 年间接受了甲状腺手术。IOH 定义为收缩压下降超过基线值的 20%。我们研究了人口统计学特征(性别、年龄、体重指数-BMI)、合并症、手术类型和持续时间以及麻醉对 IOH 发生的影响。使用单因素和多因素逻辑回归来确定 IOH 发生的预测因素。

结果

6.5%的患者出现 IOH。最常见的手术是甲状腺切除术。发生 IOH 的患者年龄较小,BMI 较低,患有高血压的合并症明显较少。多因素回归模型确定 BMI 和无高血压作为合并症,是 IOH 发生的独立预测因素。发生 IOH 的患者术后低血压的发生率明显更高(9.9%比 2.4%,p=0.000)。

结论

即使在手术时间短且出血少的情况下,IOH 也很常见。需要特别关注这些患者,因为其中许多患者在术后仍处于低血压状态。

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