Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin 2, Ireland.
Nat Rev Microbiol. 2013 May;11(5):349-55. doi: 10.1038/nrmicro3007. Epub 2013 Apr 3.
Data obtained with advanced imaging techniques, chromosome conformation capture methods, bioinformatics and molecular genetics, together with insights from polymer physics and mechanobiology, are helping to refine our understanding of the spatiotemporal organization of the bacterial nucleoid and its gene expression programmes. Here, I discuss the proposal that, in addition to DNA topology and nucleoid-associated proteins, gene regulation is an important organizing principle of nucleoid architecture.
利用先进的成像技术、染色体构象捕获方法、生物信息学和分子遗传学，以及聚合物物理和机械生物学的见解，正在帮助我们更深入地了解细菌核区的时空组织及其基因表达程序。在这里，我讨论了这样一种观点，即除了 DNA 拓扑和核区相关蛋白外，基因调控也是核区结构的一个重要组织原则。
