Xiao Ling-Han, Wang Tao, Zhao Tian-Yi, Zheng Xin, Sun Li-Ying, Li Ping, Liu Feng-Qi, Gao Ge, Dong Alideertu
College of Chemistry and MacDiarmid Laboratory, Jilin University, Changchun 130021, China.
Int J Mol Sci. 2013 Apr 2;14(4):7391-404. doi: 10.3390/ijms14047391.
Novel magnetic-antimicrobial-fluorescent multifunctional hybrid microspheres with well-defined nanostructure were synthesized by the aid of a poly(glycidyl methacrylate) (PGMA) template. The hybrid microspheres were fully characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FTIR), X-ray diffraction (XRD) and digital fluorescence microscope. The as-synthesized microspheres PGMA, amino-modified PGMA (NH2-PGMA) and magnetic PGMA (M-PGMA) have a spherical shape with a smooth surface and fine monodispersity. M-PGMA microspheres are super-paramagnetic, and their saturated magnetic field is 4.608 emu·g-1, which made M-PGMA efficiently separable from aqueous solution by an external magnetic field. After poly(haxemethylene guanidine hydrochloride) (PHGH) functionalization, the resultant microspheres exhibit excellent antibacterial performance against both Gram-positive and Gram-negative bacteria. The fluorescence feature originating from the quantum dot CdTe endowed the hybrid microspheres with biological functions, such as targeted localization and biological monitoring functions. Combination of magnetism, antibiosis and fluorescence into one single hybrid microsphere opens up the possibility of the extensive study of multifunctional materials and widens the potential applications.
借助聚甲基丙烯酸缩水甘油酯（PGMA）模板合成了具有明确纳米结构的新型磁性-抗菌-荧光多功能杂化微球。通过扫描电子显微镜（SEM）、透射电子显微镜（TEM）、傅里叶变换红外光谱（FTIR）、X射线衍射（XRD）和数字荧光显微镜对杂化微球进行了全面表征。合成的微球PGMA、氨基修饰的PGMA（NH2-PGMA）和磁性PGMA（M-PGMA）呈球形，表面光滑，具有良好的单分散性。M-PGMA微球具有超顺磁性，其饱和磁场为4.608 emu·g-1，这使得M-PGMA能够通过外部磁场从水溶液中高效分离。经聚六亚甲基胍盐酸盐（PHGH）功能化后，所得微球对革兰氏阳性菌和革兰氏阴性菌均表现出优异的抗菌性能。源自量子点CdTe的荧光特性赋予了杂化微球生物功能，如靶向定位和生物监测功能。将磁性、抗菌性和荧光性结合到单个杂化微球中，为多功能材料的广泛研究开辟了可能性，并拓宽了潜在应用范围。
